Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies.

نویسندگان

  • Pau Rocas
  • Mireia Hoyos-Nogués
  • Josep Rocas
  • José M Manero
  • Javier Gil
  • Fernando Albericio
  • Carlos Mas-Moruno
چکیده

A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.

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عنوان ژورنال:
  • Advanced healthcare materials

دوره 4 13  شماره 

صفحات  -

تاریخ انتشار 2015